The Suzaku Observations of SS Cygni in Quiescence and Outburst

We present results from the Suzaku observations of the dwarf nova SS Cyg in quiescence and outburst in 2005 November. Owing to high sensitivity of the HXD PIN detector and high spectral resolution of the XIS, we have determined parameters of the plasma with unprecedented precision. The maximum temperature of the plasma in quiescence 20.4 +4.0-2.6 (stat.) +/- 3.0 (sys.) keV is significantly higher than that in outburst 6.0 +0.2-1.3 keV. The elemental abundances are close to the solar ones for the medium-Z elements (Si, S, Ar) whereas they decline both in lighter and heavier elements. Those of oxygen and iron are 0.46 and 0.37 solar, respectively. That of carbon is exceptionally high and 2 solar at least. The solid angle of the reflector subtending over the optically thin thermal plasma is Omega/2\pi = 1.7+/-0.2 (stat.) +/-0.1 (sys.) in quiescence. A 6.4 keV iron Ka line is resolved into a narrow and broad components. These facts indicate that both the white dwarf and the accretion disk contribute to the continuum reflection and the 6.4 keV iron Ka line. We consider the standard optically thin boundary layer as the most plausible picture for the plasma configuration in quiescence. The solid angle of the reflector in outburst Omega/2\pi = 0.9 +0.5-0.4 and a broad 6.4 keV iron line indicates that the reflection in outburst originates from the accretion disk and an equatorial accretion belt. From the energy width of the 6.4 keV line, we consider the optically thin thermal plasma in outburst as being distributed on the accretion disk like solar coronae.Comment: 28 pages, 15 figures, accepted for publication in PASJ Suzaku 3rd special issue Pdf of this paper can be downloaded from http://www.astro.isas.jaxa.jp/~ishida/Papers/sscyg_sub2.pd

Confidence in expressing novel textures - an analysis of Japanese ideophones that describe visually-induced textures

Although a close relationship between the emergence of a new expression and that of either a new object or concept is presupposed in linguistic analysis, the correlation has not been pursued thoroughly. This paper investigates how people respond to different novel textures within language. We carried out an experiment using an application that displays visually-induced texture. Participants were presented with two types of novel texture: one had a time delay between touching and the texture’s response to this and the other did not. Participants were asked to describe the texture with ideophones (sound symbolic words) in Japanese. We observed what kinds of ideophones were used and the confidence with which they were expressed, which produced two results. First, there was a significant difference between the two texture types regarding confidence. For the texture with a delay, active touch was required for subjects to express it with a high level of confidence. Second, when the expressions were made with high confidence, the texture with a delay was expressed with significantly more unconventional ideophones than that without delay

Clinicopathological characteristics of patients with amyotrophic lateral sclerosis resulting in a totally locked-in state (communication Stage V)

In the present study, we performed a comprehensive analysis to clarify the clinicopathological characteristics of patients with amyotrophic lateral sclerosis (ALS) that had progressed to result in a totally locked-in state (communication Stage V), in which all voluntary movements are lost and communication is impossible. In 11 patients, six had phosphorylated TAR DNA-binding protein 43 (pTDP-43)-immunoreactive (ir) neuronal cytoplasmic inclusions (NCI), two had fused in sarcoma (FUS)-ir NCI, and three had copper/zinc superoxide dismutase (SOD1)-ir NCI. The time from ALS onset to the need for tracheostomy invasive ventilation was less than 24 months in ten patients. Regardless of accumulated protein, all the patients showed common lesions in the pallido-nigro-luysian system, brainstem reticular formation, and cerebellar efferent system, in addition to motor neurons. In patients with pTDP-43-ir NCI, patients with NCI in the hippocampal dentate granule neurons (DG) showed a neuronal loss in the cerebral cortex, and patients without NCI in DG showed a preserved cerebral cortex. By contrast, in patients with FUS-ir NCI, patients with NCI in DG showed a preserved cerebral cortex and patients without NCI in DG showed marked cerebral degeneration. The cerebral cortex of patients with SOD1-ir NCI was preserved. Together, these findings suggest that lesions of the cerebrum are probably not necessary for progression to Stage V. In conclusion, patients with ALS that had progressed to result in communication Stage V showed rapidly-progressed symptoms, and their common lesions could cause the manifestations of communication Stage V.ArticleACTA NEUROPATHOLOGICA COMMUNICATIONS.4:107(2016)journal articl

A new therapeutic strategy with istradefylline for postural deformities in Parkinson’s disease

Aim of the study. Postural deformities are common in Parkinson’s disease (PD) patients. Several treatment options have been reported, but responses to these treatments appear unpredictable. Istradefylline is a novel drug for PD. Cases of PD patients whose postural deformities were improved after withdrawal of dopamine agonists and initiation of istradefylline are presented. Materials and Methods. Four consecutive patients with postural deformities including antecollis, Pisa syndrome, and camptocormia were recruited and treated with istradefylline in combination with withdrawal of dopamine agonists, which are possible causes of postural deformities. Results. The dopamine agonists were discontinued an average of 26 months after the development of the postural deformities, and istradefylline was initiated an average of 1.3 months after dopamine agonist withdrawal. Three patients with preserved paraspinal muscle volume showed good responses to the treatment regimen at least two months after dopamine agonist withdrawal. Conclusions and clinical Implications. Postural deformities caused by dopamine agonists generally improve less than two weeks after dopamine agonist withdrawal. Given the response time in the present study, the response was unlikely to be caused solely by dopamine agonist withdrawal. Istradefylline can be a potential therapeutic option; however, appropriate selection of patients for treatment with istradefylline is warranted

Molecular Dissection of the α-Dystroglycan- and Integrin-binding Sites within the Globular Domain of Human Laminin-10

This research was originally published in the Journal of Biological Chemistry. Hiroyuki Ido, Kenji Harada, Sugiko Futaki, Yoshitaka Hayashi, Ryoko Nishiuchi, Yuko Natsuka, Shaoliang Li, Yoshinao Wada, Ariana C. Combs, James M. Ervasti and Kiyotoshi Sekiguchi. Molecular Dissection of the α-Dystroglycan- and Integrin-binding Sites within the Globular Domain of Human Laminin-10. J. Biol. Chem. 2004; 279: 10946-10954 © the American Society for Biochemistry and Molecular Biolog

Suzaku Discovery of Hard X-ray Pulsations from the Rotating Magnetized White Dwarf, AE Aquarii

The fast rotating magnetized white dwarf, AE Aquarii, was observed with Suzaku, in October 2005 and October 2006 with exposures of 53.1 and 42.4 ks, respectively. In addition to clear spin modulation in the 0.5--10 keV band of the XIS data at the barycentric period of 33.0769 \pm 0.0001 s, the 10--30 keV HXD data in the second half of the 2005 observation also showed statistically significant periodic signals at a consistent period. On that occasion, the spin-folded HXD light curve exhibited two sharp spikes separated by about 0.2 cycles in phase, in contrast to approximately sinusoidal profiles observed in energies below about 4 keV. The folded 4--10 keV XIS light curves are understood as a superposition of those two types of pulse profiles. The phase averaged 1.5--10 keV spectra can be reproduced by two thermal components with temperatures of $2.90_{-0.16}^{+0.20}$ keV and $0.53_{-0.13}^{+0.14}$ keV, but the 12-25 keV HXD data show a significant excess above the extrapolated model. This excess can be explained by either a power-law model with photon index of $1.12_{-0.62}^{+0.63}$ or a third thermal component with a temperature of $54_{-47}^{+26}$ keV. At a distance of 102 pc, the 4--30 keV luminosities of the thermal and the additional components become $1.7_{-0.6}^{+1.3}$ and $5.3_{-0.3}^{+15.3} \times 10^{29}$ erg s$^{-1}$, respectively. The latter corresponds to 0.09% of the spin down energy of the object. Possible emission mechanisms of the hard pulsations are discussed, including in particular non-thermal ones.Comment: Accepted for publication on PASJ Vol.60, No.2, 2008 see Press Release page(http://www.heal.phy.saitama-u.ac.jp/~terada/01work/press_release2008/index_e.html

Role of Sphingomyelinase in Infectious Diseases Caused by Bacillus cereus

Bacillus cereus (B. cereus) is a pathogen in opportunistic infections. Here we show that Bacillus cereus sphingomyelinase (Bc-SMase) is a virulence factor for septicemia. Clinical isolates produced large amounts of Bc-SMase, grew in vivo, and caused death among mice, but ATCC strains isolated from soil did not. A transformant of the ATCC strain carrying a recombinant plasmid containing the Bc-SMase gene grew in vivo, but that with the gene for E53A, which has little enzymatic activity, did not. Administration of an anti-Bc-SMase antibody and immunization against Bc-SMase prevented death caused by the clinical isolates, showing that Bc-SMase plays an important role in the diseases caused by B. cereus. Treatment of mouse macrophages with Bc-SMase resulted in a reduction in the generation of H2O2 and phagocytosis of macrophages induced by peptidoglycan (PGN), but no effect on the release of TNF-α and little release of LDH under our experimental conditions. Confocal laser microscopy showed that the treatment of mouse macrophages with Bc-SMase resulted in the formation of ceramide-rich domains. A photobleaching analysis suggested that the cells treated with Bc-SMase exhibited a reduction in membrane fluidity. The results suggest that Bc-SMase is essential for the hydrolysis of SM in membranes, leading to a reduction in phagocytosis

Pathological and radiological correlation in an autopsy case of combined pulmonary fibrosis and emphysema

We report an educational autopsy case of combined pulmonary fibrosis and emphysema. Radiological patterns of the upper lung were considered as mostly emphysema, but pathological observation revealed significant interstitial fibrosis of usual interstitial pneumonia as a major pathology. The patient eventually developed acute exacerbation of background interstitial pneumonia. Careful radiological and pathological correlation of the current case indicates that regions with distal acinar emphysema on computed tomography image may possess histologically marked dense fibrosis of lethal interstitial pneumonia